The acquired immune system's lymphocytes (T cells and B cells) attack antigens like bacteria and viruses, and create antibodies that prevent re-infection.
The innate immune system includes skin and other barriers which prevent disease entering the body, and inflammatory and other responses which fight disease.
Localised scleroderma refers to thickening of the skin as a result of connective tissue accumulation. It may cause swelling, plaques or other skin lesions.