Sulphonamides and Trimethoprim are used in conjunction to form a antibiotic that fights bacteria. Sulfamethoxazole is the only commonly used local sulphonamide, and is combined with the antibiotic Trimethoprim to form Co-trimoxazole. It inhibits tetrahydrofolic acid, which is used by bacteria to form purines. Sulphonamides are analogues of p-aminobenzoic acid and competitively inhibit formation of the bacterial enzyme – dihydropteroic acid synthetase
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