Infections
01 Jan 2013
Anti-HIV Drug Regimens With or Without Protease Inhibitors and Drug Level Monitoring in HIV Infected Adolescents
Purpose This study will compare the effectiveness of anti-HIV drug regimens with or without a protease inhibitor (PI) in HIV infected adolescents. It will also determine if monitoring drug levels and adjusting the dose as necessary improves the effectiveness of these regimens. Purpose This study will compare the effectiveness…
Infections
01 Jan 2013
OPTIMA (Options in Management with Anti-Retrovirals)
Purpose This ‘pragmatic’ trial is a 2X2 open randomized study of patients in advanced HIV disease who have failed on conventional HAART (Highly Active Antiretroviral Therapy) regimens including all three classes of anti-HIV drugs. The first randomization will allocate patients to an intended 3-month antiretroviral drug-free period (ARDFP) or…
Mental Health
01 Jan 2013
Preliminary Human Trial of NPI-028
This research will determine whether the Chinese herbal medicine (NPI-028) can make a significant contribution to the management of withdrawal and to follow-up treatment aimed at preventing or managing relapse in both women and men alcoholics. The herbal preparation has been used historically in the treatment of alcohol intoxication and…
Heart
01 Jan 2013
ARISE (Aggressive Reduction of Inflammation Stops Events)
To assess the safety and efficacy of AGI-1067, as compared to placebo, in the treatment of vascular inflammation and atherosclerosis by assessing the reduction in cardiovascular events. To assess the safety and efficacy of AGI-1067, as compared to placebo, in the treatment of vascular inflammation and atherosclerosis by assessing the…
Blood
01 Jan 2013
Aggressive vs. conservative red blood cell transfusion therapy in surgical patients with Cardiovascular Disease
Purpose: To compare aggressive with conservative red blood cell transfusion therapy in surgical patients with cardiovascular disease. Official Title Conditions – Anemia- Blood Disease- Blood Transfusion- Cardiovascular Diseases- Heart Diseases- Myocardial Infarction- Thromboembolism- Pneumonia- Cerebrovascular Accident Study Type Interventional Study Design Preventional, Randomised. Further Details BACKGROUND: Red blood cell…
Cancer
01 Jan 2013
Specialized Blood Cell Transplants for Cancers of the Blood and Bone Marrow
Purpose The are a variety of cancerous diseases of the blood and bone marrow that can be potentially cured by bone marrow transplantation (BMT). Diseases like leukemia, lymphoma, and multiple myeloma are among the conditions that can be treated with BMT. Official Title Non-myeloablative Allogeneic Peripheral Blood Mobilized Hematopoietic…
Infections
01 Jan 2013
Identification of new organelle in apicomplexan parasites which can serve as a drug target.
The recent discovery of a new organelle in several parasites including Toxoplasma, Plasmodium (malaria) and Eimeria has received considerable attention, but its function was unknown. Official Title Conditions Study Type Study Design Further Details NIAID supported investigators investigated this role usnign parasiticidal treatments against the organelle, called an apicoplast. Molecular…
Heart
01 Jan 2013
STOPAMI
Prevention of myocardial damage is the main goal of all reperfusion therapies in patients with acute myocardial infarction. The relative efficacy of various reperfusion strategies is under intensive investigation. We assessed whether coronary stenting combined with the blockade of platelet glycoprotein IIb/IIIa receptors produces a greater degree of myocardial salvage…
Heart
01 Jan 2013
RAPPORT
The benefit of catheter-based reperfusion for acute myocardial infarction (MI) is limited by a 5 % to 15 % incidence of in-hospital major ischemic events, usually caused by infarct artery reocclusion, and a 20 % to 40 % need for repeat percutaneous or surgical revascularization. Platelets play a key role…
