Heart
01 Jan 2013
FREEDOM-C: Oral Treprostinil in Combination With an Endothelin Receptor Antagonist (ERA) and/or a Phosphodiesterase-5 (PDE-5) Inhibitor for the Treatment of Pulmonary Arterial Hypertension (PAH)
This study is an international, multi-center, randomized, double-blind, placebo-controlled study in subjects with PAH who are currently receiving approved therapy for their PAH (i.e. endothelin receptor antagonist and/or phosphodiesterase-5 inhibitor). Study visits will occur at 4 week intervals for 16 weeks with the key measure of efficacy being the 6-minute…
Cancer
01 Jan 2013
Breast Cancer Trial of an Investigational Drug Versus Capecitabine in Male or Female Patients With Advanced Breast Cancer
The purpose of this clinical trial is to determine if the investigational drug is a better treatment than capecitabine (Xeloda) for advanced breast cancer in patients that no longer benefit from docetaxel and/or paclitaxel. Official Title A Randomized, Open-Label, Phase III Study of an Investigational Drug IV Every 3 Weeks…
Cancer
01 Jan 2013
Vaccination Therapy in Treating Patients With Limited-Stage Small Cell Lung Cancer
Randomized phase III trial to compare the effectiveness of vaccination with monoclonal antibody BEC2 and BCG with that of no further therapy in treating patients who have limited-stage small cell lung cancer. Official Title The SILVA Study: Survival in an International Phase III Prospective Randomized LD Small Cell Lung Cancer…
Cancer
01 Jan 2013
A Study of Xeloda (Capecitabine) Plus Oxaliplatin in Patients With Colon Cancer
This study will compare the efficacy and safety of intermittent oral Xeloda plus Eloxatin with that of fluorouracil/leucovorin in patients who have had surgery for colon cancer and no previous chemotherapy. The anticipated time on study treatment is until disease progression and the target sample size is 500+ individuals. Official…
Cancer
01 Jan 2013
A Multi-Center Study of E7389 Versus Treatment of Physician’s Choice in Patients With Locally Recurrent or Metastatic Breast Cancer
The primary objective of this study is to compare Overall Survival (OS) in patients treated with E7389 versus the Treatment of Physician’s Choice (TPC) in patients with locally recurrent or metastatic breast cancer. Secondary objectives are to assess: Progression Free Survival (PFS) Objective Tumor Response Rate as measured…
Research and Trials
01 Jan 2013
Neurobiological Predictors of Huntington’s Disease (PREDICT-HD)
The purpose of this trial is to study early brain and behavioral changes in people who have the gene expansion for Huntington’s disease, but are currently healthy and have no symptoms. Official Title Neurobiological Predictors of Huntington’s Disease Trial Conditions Huntington Disease Study Type Observational Study Design Natural History Further…
Chronic Pain
01 Jan 2013
Efficacy Of Pregabalin In Subjects With Post-Stroke Pain
Efficacy of pregabalin in subjects with post-stroke pain. Official Title A 13-Week, Randomized, Multi-Centre, Double-Blind, Placebo-Controlled, Parallel-Group, Phase IV Study To Evaluate The Efficacy, Safety And Tolerability Of Pregabalin (150-600 Mg/Day) Using A Flexible Dosing Schedule In The Treatment Of Subjects With Central Post-Stroke Pain (CPSP). Conditions Central Nervous…
Research and Trials
01 Jan 2013
Study of Apixaban for the Prevention of Thrombosis-Related Events Following Knee Replacement Surgery
Study of Apixaban for the Prevention of Thrombosis-Related Events Following Knee Replacement Surgery medical clinical research trial
Cancer
01 Jan 2013
A Randomized Controlled Trial Comparing Safety and Efficacy of Carboplatin and Paclitaxel Plus or Minus Sorafenib (BAY 43-9006) in Chemonaive Patients With Stage IIIB-IV Non-Small Cell Lung Cancer (NSCLC)
A Randomized Controlled Trial Comparing Safety and Efficacy of Carboplatin and Paclitaxel Plus or Minus Sorafenib (BAY 43-9006) in Chemonaive Patients With Stage IIIB-IV Non-Small…
