Cancer
01 Jan 2013
Comparison of Radiation Therapy Regimens in Combination With Chemotherapy in Treating Young Patients With Newly Diagnosed Standard-Risk Medulloblastoma
This randomized phase III trial is studying standard-dose radiation therapy to see how well it works compared to reduced-dose craniospinal radiation therapy AND posterior fossa boost radiation therapy to see how well it works compared to tumor bed boost radiation therapy when given together with chemotherapy in treating young patients…
Chronic Pain
01 Jan 2013
Oral Dexamethasone for Treatment of Migraine
The aim of this project is to determine if a single dose of oral dexamethasone at the time of discharge from the ED prevents rebound headache. Official Title Does a Single Oral Dose of Dexamethasone After Successful Emergency Treatment of Migraine Reduce the Incidence or Severity of Rebound Headache Within…
Mental Health
01 Jan 2013
Efficacy of Seroquel SR in Combination With an Antidepressant in Treatment of Major Depressive Disorder (ONYX)
To evaluate the efficacy of quetiapine fumarate sustained release (Seroquel SR) in combination with an antidepressant versus an antidepressant alone in patients with Major Depressive Disorder. Official Title A Multi-Centre, Double-Blind, Randomised, Parallel-Group, Placebo-Controlled Phase III Study of the Efficacy and Safety of Quetiapine Fumarate Sustained Release (Seroquel SRTM) in…
Mental Health
01 Jan 2013
A Study of Risperidone Long-Acting Injection Versus Oral Antipsychotics in Schizophrenia Patients With a History of Being Poorly Compliant With Taking Their Medication
The purpose of this study is to evaluate risperidone long-acting injection (an antipsychotic medication) versus oral antipsychotics in schizophrenia patients with a history of being poorly compliant with taking their medication. Official Title Pragmatic Randomized Trial of ‘Risperdal CONSTA’ (Risperidone) Versus Oral Atypical Antipsychotics in Poorly Adherent Subjects With Schizophrenia…
Mental Health
01 Jan 2013
Treatment of Comorbid Depression and Substance Abuse in Young People
This study aims to treat young people with an adjunctive integrated Cognitive Behaviour Therapy (CBT) intervention and to examine the acceptability of this treatment approach within this population. The study will also include a pilot placebo-controlled trial of sertraline for those young people who fail to or only partially respond…
Mental Health
01 Jan 2013
Trial for the Treatment of Alcohol Dependence
The purpose of this study is to compare the effectiveness of two anti-craving medications, naltrexone versus acamprosate, in the treatment of alcohol dependence. Official Title The Role of Pharmacotherapy in Prevention of Relapse in Alcohol Dependence Conditions Alcoholism Study Type Interventional Study Design Treatment, Randomized, Double-Blind, Placebo Control, Parallel Assignment,…
Children's health
01 Jan 2013
Long-Term, Open Label Atomoxetine Study on Attention Deficit Hyperactivity Disorder
To learn about the safety and any side effects of atomoxetine when given to children and adolescents for about 5 years (long-term) and to learn whether atomoxetine can help children and adolescents with ADHD who take the drug for about 5 years (long-term). Official Title Long-Term, Open Label Safety Study…
Heart
01 Jan 2013
Panic Disorder and Cardiac Risk
The reason for increased cardiac mortality in panic disorder has not been precisely identified, but possibly is due to chronic activation of the cardiac stimulant (sympathetic) nerves, which may predispose the individual with panic disorder to disorders of cardiac rhythm and coronary artery spasm. The uniqueness of this study lies…
Mental Health
01 Jan 2013
An Eight-Week Study to Evaluate the Efficacy and Safety of 2 Doses of Saredutant in Patients With Generalized Anxiety Disorder
The primary objective is to evaluate the efficacy of two fixed doses (100 mg and 30 mg once daily) of saredutant compared to placebo in patients with generalized anxiety disorder. The secondary objectives are to evaluate the efficacy of saredutant on disability and quality of life in patients with generalized…
