Children's health
01 Jan 2013
Rosiglitazone and Insulin in T1DM Adolescents
Type 1 Diabetes is the most common life-long disorder with onset in childhood. Patients need insulin injections, blood sugar monitoring several times each day, and adhere to a strict diet. Adequate control of blood glucose is essential to prevent long term kidney and eye complications that result in kidney failure…
Children's health
01 Jan 2013
Predictive Markers in GHD and TS Children Treated With ‘SAIZEN’
The study aims at identifying the predictive markers after one month of Saizen therapy in Growth Hormone Deficiency (GHD) and Turner Syndrome children. The study will recruit approximately 360 children in several countries worldwide. The study lasts for about the first one month of daily growth hormone treatment. There will…
Children's health
01 Jan 2013
Trial of Intranasal Insulin in Children and Young Adults at Risk of Type 1 Diabetes
In people with type I diabetes the beta cells of the pancreas no longer make insulin because the body’s immune system has attacked and destroyed the beta cells. It is thought that exposure of the mucous membranes to insulin may cause act like a vaccine effect whereby protective immune cells…
Cancer
01 Jan 2013
Combination Chemotherapy Plus Radiation Therapy in Treating Children With Newly Diagnosed Brain Stem Glioma
Phase I trial to study the effectiveness of vincristine plus etoposide and radiation therapy in treating children who have newly diagnosed brain stem glioma.Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor…
Children's health
01 Jan 2013
Hib-MenCY-TT Vaccine Study Compared to Licensed Hib and Meningococcal Serogroup C Conjugate Vaccines
This study is evaluating the safety and immunogenicity of Hib-MenCY-TT vaccine compared to control groups receiving licensed Hib or MenC conjugate vaccines, each administered at 2, 4, 6, and 12 to 15 months of age. Co-administration with live, attenuated measles, mumps, and rubella combination vaccine; and with live, attenuated varicella…
Children's health
01 Jan 2013
Study Evaluating Safety & Immunogenicity of rLP2086 Meningitis Vaccine in Adolescents
Study to evaluate the safety of an investigational meningitis vaccine and the immune response to it in adolescents Official Title A Randomized, Observer-Blinded, Parallel-Group, Active-Control, Phase 1/2 Trial of the Safety, Immunogenicity, and Tolerability of 20 micrograms, 60 micrograms, and 200 micrograms of Meningococcal Group B rLP2086 Vaccine in Healthy…
Children's health
01 Jan 2013
Prevention of Asthma With Levocetirizine (36 Month Treatment) in Young Children Suffering From Eczema (Atopic Dermatitis) and Sensitized to Grass Pollen and House Dust Mite and Having Completed the Previous EPAAC Trial
36 months study to evaluate the efficacy and safety of levocetirizine (LCTZ) in preventing the onset of asthma in young atopic children. Official Title The Prolongation of the EPAAC Trial (The Early Prevention of Asthma in Atopic Children). A Multi-Country, Double Blind, Placebo (PLC) Controlled, Follow-up Trial With 3 Parallel…
Cancer
01 Jan 2013
The IVADo regimen for children with metastatic soft tissue sarcoma
Objectives: To evaluate the feasibility of an intensified induction regimen (IVADo), which combines doxorubicin, with the well established ifosfamide, vincristine and actinomycin D (IVA) regimen. Conclusions from the authors: The intensive IVADo regimen was effective against pediatric STS with acceptable toxicity. This combination will be investigated in high-risk…
Blood
01 Jan 2013
Transfusion Medicine/Hemostasis Clinical Research Network
To establish a clinical network which will promote the efficient comparison of new management strategies of potential benefit for children and adults with hemostatic disorders such as idiopathic thrombocytopenia (ITP) and thrombotic thrombocytopenic purpura (TTP). The network also will evaluate new as well as existing blood products and cytokines for…
