Chronic Pain
01 Jan 2013
Flecainide in Treating Patients With Chronic Neuropathic Pain
RATIONALE: Flecainide therapy may help patients with neuropathic pain live more comfortably. Official Title Phase II Study of Flecainide for the Treatment of Chronic Neuropathic Pain Conditions – Pain Study Type Interventional Study Design Treatment Further Details OBJECTIVES:Investigate the effectiveness of flecainide in the management of neuropathic pain. OUTLINE: Patients…
Neurology
01 Jan 2013
Minocycline in Patients with Huntington’s Disease
This is a study to determine whether treatment with minocycline is safe and tolerable in patients with Huntington’s disease (HD) and whether minocycline reduces symptoms of HD in these patients. Official Title Conditions – Huntington’s Disease Study Type Interventional Study Design Treatment, Randomized, Double-Blind, Placebo Control, Safety/Efficacy Study Further…
Infections
01 Jan 2013
Genetics of Hepatitis C Virus Infection
The course of hepatitis C varies among people infected with the virus. Some people respond to treatment while many do not; some recover completely while others remain chronically infected; and among those who remain infected, some have mild symptoms while others’ symptoms are severe. This study will look for genetic…
Infections
01 Jan 2013
Long-Term Therapy with Ribavirin for Chronic Hepatitis C
Chronic hepatitis C is a disease of the liver caused by the hepatitis C virus. The disease can be serious and even fatal. Approximately 25% of patients with chronic hepatitis C will develop cirrhosis and some of these patients will develop cancer of the liver or liver failure. Official Title…
Gastro
01 Jan 2013
Free-Living Physical Activity and Energy Expenditure
We have recently validated a new device for measurement of physical activity and found it to detect type, duration and intensity of many types of physical activity at better than 98% accuracy. After further validating this device to determine if it can also accurately assess energy expenditure, we will use…
Neurology
01 Jan 2013
Droxidopa in Treating Patients With Neurogenic Hypotension
RATIONALE: Neurogenic hypotension is a fall in blood pressure that occurs when one moves from a lying down to a standing position or after eating a meal. It causes one to feel dizzy, light headed, and weak. Neurogenic hypotension is caused by a problem in the part of the nervous…
Heart
01 Jan 2013
A safety and efficacy trial evaluating the use of SanOrg34006 in the treatment of Deep Vein Thrombosis (DVT)
Patients who have deep vein thrombosis (blood clot in the leg) will be treated in this study. The purpose of the study is to compare the safety and effectiveness of a new injectible anticoagulant (blood thinning) drug administered once each week, SanOrg34006, with the standard way of treating deep vein…
Heart
01 Jan 2013
Stenting vs. Surgery to Prevent Stroke
The purpose of the Carotid Revascularization Endarterectomy versus Stenting Trial (CREST) is to compare the relatively new procedure of stent-assisted carotid angioplasty (CAS) to the traditional and accepted surgical approach of carotid endarterectomy (CEA) for the treatment of carotid artery stenosis to prevent recurrent strokes in those patients who have…
Heart
01 Jan 2013
Efficacy and Safety of Azimilide in the Prophylactic Treatment of Patients With Atrial Fibrillation
Atrial fibrillation (an abnormal rhythm in the upper chamber of the heart) is a common supraventricular arrhythmia (a type of abnormal heart rhythm) for which antiarrhythmic therapy is often prescribed. The primary goals of therapy are to maintain sinus rhythm (normal heart rhythm) and to reduce the occurrence of episodes…
