Heart
01 Jan 2013
Air Pollution and Implantable Cardioverter Defibrillators
Community based studies have shown increased cardiovascular mortality associated with acute exposures to particulate air pollution. Electrocardiographic changes have also been reported in animals exposed to particles in controlled conditions. We have hypothesized that cardiovascular patients may experience life-threatening arrhythmias associated with particulate air pollution episodes. Implanted cardioverter defibrillator (ICD)…
Cancer
01 Jan 2013
Genetic Study of Young Patients With Colorectal Cancer
RATIONALE: Identifying genemutations (microsatellite instability) may allow doctors to plan effective treatment for patients who develop colorectal cancer at an early age. Official Title Genetic Study of the Prognostic Significance of Microsatellite Instability in Patients With Early Age-of-Onset Stage I-III Colorectal Cancer Conditions – Colon Cancer- hereditary non-polyposis colon…
Cancer
01 Jan 2013
Lycopene in Treating Patients With Metastatic Prostate Cancer
RATIONALE: Lycopene, a substance found in tomatoes, may lower prostate-specific antigen (PSA) levels and slow or prevent the development of prostate cancer. RATIONALE: Lycopene, a substance found in tomatoes, may lower prostate-specific antigen (PSA) levels and slow or prevent the development of prostate cancer. PURPOSE: Phase II trial to study…
Heart
01 Jan 2013
Registry of Fabry Disease – A Multicenter Observational Study
The purpose of this study is to compile a registry of patients with Fabry disease, an inherited metabolic disorder. In this disease, an enzyme called a-galactosidase A, which normally breaks down a lipid (fatty substance) called globotriaosylceramide (Gb3), is missing or does not function properly. As a result, Gb3 accumulates,…
Heart
01 Jan 2013
The Role of Heart Stiff and Weak Atrium on Exercise Capacity in Patients with Hypertrophic Cardiomyopathy
This study will examine how heart stiffness and a weak atrium affect exercise capacity and symptoms in patients with hypertrophic cardiomyopathy (HCM). The atrium is the booster pumping chamber of the heart that helps the ventricle (main pumping chamber), to fill properly. HCM is an inherited disease in which the…
Cancer
01 Jan 2013
Tumor Vaccine and Interferon gamma in Treating Patients With Refractory Epithelial Ovarian Cancer
RATIONALE: Vaccines made from a person’s cancer cells may make the body build an immune response to and kill their tumor cells. Combining vaccine therapy with interferon gamma may be a more effective treatment for epithelial ovarian cancer. RATIONALE: Vaccines made from a person’s cancer cells may make the body…
Cancer
01 Jan 2013
Low-Fat Diet and/or Flaxseed in Preventing Prostate Cancer
RATIONALE: A diet that is low in fat and/or high in flaxseed may slow or prevent disease progression of prostate cancer. RATIONALE: A diet that is low in fat and/or high in flaxseed may slow or prevent disease progression of prostate cancer.PURPOSE: Randomizedphase II trial to study the effectiveness of…
Cancer
01 Jan 2013
Combination Chemotherapy in Treating Patients With Liver Metastases from Colorectal Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more cancer cells. It is not yet known which chemotherapy regimen is more effective for metastatic colorectal cancer. PURPOSE: Randomizedphase III trial…
Cancer
01 Jan 2013
Imiquimod in Preventing Cervical Cancer in Women With Cervical Neoplasia
RATIONALE: Chemoprevention therapy is the use of certain substances to try to prevent the development of cancer. Applying topicalimiquimod before abnormal cervical cells are removed may be effective in preventing cervical cancer. RATIONALE: Chemoprevention therapy is the use of certain substances to try to prevent the development of cancer. Applying…
