Cancer
01 Jan 2013
FOLFOX4 in Patients with Normal and Abnormal Renal Function
This trial is a phase II study of patients with advanced gastrointestinal (GI) malignancies who will be assigned to one of 4 cohorts (normal, mild dysfunction, moderate dysfunction and severe renal dysfunction) based on their baseline measured creatinine clearance then treated with FOLFOX4. Standard bone marrow and liver function…
Blood
01 Jan 2013
SR34006 Compared to Placebo in Patients who have Completed 6 Months of Treatment for Symptomatic Pulmonary Embolism or Deep Vein Thrombosis
Patients diagnosed with pulmonary embolism (blood clot in the lung) or deep vein thrombosis (blood clot in a leg vein) are at risk for these blood clots to reoccur. Anticoagulant (blood-thinning) drugs are normally given immediately after the clot is discovered and are continued for a period of 3 or…
Lungs
01 Jan 2013
FLASH Study: A study of roflumilast versus placebo in patients with asthma
The purpose of this study is to determine whether roflumilast is effective in the treatment of asthma. Official Title FLASH Study: A 24 week randomized, controlled study of roflumilast versus placebo in patients with asthma Conditions Asthma Study Type Interventional Study Design Treatment, Randomized, Double-Blind, Placebo Control, Parallel Assignment, Safety/Efficacy…
Chronic Pain
01 Jan 2013
Pain Management Techniques for Fibromyalgia
Pain management techniques may influence how the brain processes pain and may help patients with fibromyalgia (FM), a chronic pain condition. This study will train patients with FM to use pain management techniques. Investigators will use brain scanning (functional magnetic resonance imaging, or fMRI) technology to identify changes in how…
Cancer
01 Jan 2013
Maintenance ZD1839 (IRESSA®) Following Completion of Front Line, Platinum-Based, Double Chemotherapy in Subjects with Advanced or Metastatic Non-Small Cell Lung Cancer
In this Phase IIIb, randomized, double-blind, maintenance study, 300 subjects with advanced or metastatic Non-Small Cell Lung Cancer (NSCLC) (Stage IIIB {T4-pleural effusion} and IV) who have SD or objective tumor response immediately following the completion of 4-6 cycles of front line, platinum-based, doublet chemotherapy will be randomized in a…
Bone
01 Jan 2013
Study Compares Treatments for Women with Postmenopausal Osteoporosis
Once-weekly alendronate 70 mg and once-weekly risedronate 35 mg are indicated for the treatment of postmenopausal osteoporosis. These two agents were compared in a 12-month head-to-head trial. Greater gains in BMD and greater reductions in markers of bone turnover were seen with alendronate compared with risedronate with similar tolerability.
Children's health
01 Jan 2013
Quetiapine Fumarate (SEROQUEL) Compared to Placebo in the Treatment of Children and Adolescent Patients with Bipolar I Mania
The purpose of this study is to demonstrate efficacy and safety of quetiapine fumarate (SEROQUEL) compared with placebo in the treatment of children and adolescent patients with Bipolar I mania. Official Title Conditions Bipolar Disorder Study Type Interventional Study Design Treatment, Placebo Control, Safety/Efficacy Study Further Details Study Start…
Infections
01 Jan 2013
Linezolid in the Treatment of Subjects with Nosocomial Pneumonia Proven to be due to Methicillin-Resistant Staphylococcus Aureus
Linezolid is the first of a new class of antibiotics with a unique mechanism of action against Methicillin-Resistant Staphylococcus Aureus (MRSA). This is a Phase IV, double-blinded, randomized study for patients with hospital acquired pneumonia proven to be caused by MRSA. Patients will be treated with linezolid or vancomycin for…
Heart
01 Jan 2013
Comparison of sulfonamide COX-2 inhibitors and NSAIDs for cardiovascular risk
Clinical investigations have demonstrated a link between use of the sulfone cyclooxygenase-2 (COX-2) inhibitor, rofecoxib, and increased risk for atherothrombotic events. This increased risk was not observed for a sulfonamide COX-2 inhibitor (celecoxib), indicating a potential non-enzymatic mechanism for rofexocib. To test this hypothesis, researchers compared the independent effects…
