Research and Trials
01 Jan 2013
Effect of Pantoprazole on the Symptoms of Acid Reflux Disease in Adult Patients (BY1023/M3-341)
The aim of the present study is to identify factors (such as symptom patterns and symptom scores) that influence the response to treatment with pantoprazole using different evaluation methods (e.g. ‘ReQuest’ questionnaire, patient and investigator assessment). Pantoprazole will be administered once daily in the morning at one dose level. The…
Gastro
01 Jan 2013
The Rabeprazole and Esomeprazole Reflux Assessment Trial (TREAT)
The primary objective of this study is to compare, the number of patients with heartburn and regurgitation symptom resolution after treatment with either rabeprazole 20 mg, esomeprazole 20 mg or esomeprazole 40 mg. Official Title A Study to Compare the Number of Patients With Gastro-Oesophageal Reflux Disease (GORD) Achieving Heartburn…
Research and Trials
01 Jan 2013
Audit of the Effect of Changing From Intravenous to Subcutaneous Administration of Erythropoeisis Stimulating Agents in Haemodialysis Patients
The purpose of this study is to audit the effects of changing all haemodialysis patients from intravenous to subcutaneous administration of ESA’s, to ensure that a cost-saving is achieved and that this does not occur at the expense of anaemia control. The dose changes will occur according to usual clinical…
Cancer
01 Jan 2013
Cisplatin Plus Gemcitabine With or Without Paclitaxel in Treating Patients With Stage IV Urinary Tract Cancer
Randomized phase III trial to compare the effectiveness of cisplatin plus gemcitabine with or without paclitaxel in treating patients who have stage IV urinary tract cancer. Official Title Randomized Phase III Study Comparing Paclitaxel/Cisplatin/Gemcitabine and Cisplatin/Gemcitabine in Patients With Metastatic or Locally Advanced Urothelial Cancer Without Prior Systemic Therapy…
Cancer
01 Jan 2013
Intralesional PV-10 Chemoablation of Metastatic Melanoma
The objective of this study is to investigate the safety of intralesional (IL) PV-10 for the treatment of metastatic melanoma. This study will also include a preliminary assessment of response of treated and untreated lesions by clinical evaluation at follow-up of 12 to 24 weeks following IL PV-10 treatment. Official…
Cancer
01 Jan 2013
Study of “NY-ESO-1 ISCOMATRIX” in Patients With High-Risk, Resected Melanoma
The purpose of this trial is to assess whether treatment with “NY-ESO-1 ISCOMATRIX” vaccine improves outcomes for people with Malignant Melanoma which has been removed, but is at high risk of relapse. Official Title Randomized, Double-Blind Phase II Trial of “NY-ESO-1 ISCOMATRIX” Vaccine and “ISCOMATRIX” Adjuvant Alone in Patients With…
Research and Trials
01 Jan 2013
Safety Study of Herpes Simplex Vaccine in HSV Seronegative and Seropositive Females Between 10 and 17 Years Old
Main goal of this study is to compare the occurrence of serious adverse events (SAEs) between the herpes simplex (gD2-AS04) vaccine group and the Saline control group throughout the study period (up to month 12). Official Title A Study to Evaluate the Immunogenicity and Safety of GlaxoSmithKline Biologicals Herpes Simplex…
Cancer
01 Jan 2013
A Safety Study of Two Intratumour Doses of Coxsackievirus Type A21 in Melanoma Patients.
The purpose of the study is to determine the safety and tolerability of two doses of Coxsackievirus A21, administered 48 hours apart into a superficial melanoma tumour. Injected and non-injected tumours will be observed regarding change in tumour size. Official Title A Phase I, Open Label, Cohort Study of Two…
Research and Trials
01 Jan 2013
A Study of BMS-582949 in Patients With Moderate to Severe Plaque Psoriasis
The purpose of this clinical research study is to learn if BMS-582949 alone is an effective treatment for moderate to severe psoriasis. The safety of the drug and the effectiveness of each dose will also be studied. Official Title A Phase IIa, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Clinical…
