Cancer
01 Jan 2013
Chemoradiotherapy in Patients with Localised Lung Cancer
The study compares 2 different methods of combined chemotherapy and radiotherapy for the treatment of localised lung cancer in patients not suitable for surgery. Hypothesis(es) to be tested: 1) Vinorelbine + cisplatin + high-dose palliative radiotherapy is superior to gemcitabine + high dose palliative radiotherapy in terms of efficacy…
Cancer
01 Jan 2013
The IVADo regimen for children with metastatic soft tissue sarcoma
Objectives: To evaluate the feasibility of an intensified induction regimen (IVADo), which combines doxorubicin, with the well established ifosfamide, vincristine and actinomycin D (IVA) regimen. Conclusions from the authors: The intensive IVADo regimen was effective against pediatric STS with acceptable toxicity. This combination will be investigated in high-risk…
Cancer
01 Jan 2013
IEV and autologous peripheral blood progenitor cell transplant salvage treatment for lymphoid malignancies
Primary endpoints were to confirm the feasibility and efficacy of IEV in poor risk Hodgkin’s lymphoma and aggressive NHLs. Additional endpoints were to try to evaluate its possible role in the salvage strategy of indolent NHLs, lymphoblastic lymphoma and multiple myeloma. Analysis of toxicity and PBSC mobilization. Conclusions…
Cancer
01 Jan 2013
Head and Neck Phase III Iressa Vs Methotrexate Refractory. Iressa Vs Methotrexate (IMEX)
Purpose- This study is to compare ZD1839 (250mg and 500mg) versus methotrexate in head and neck cancer in terms of overall survival. Official Title A Phase III Randomised, Stratified, Parallel-Group, Mulit-Centre, Comparative Study of ZD1839 (Iressa) 250 mg and 500 mg Versus Methotraxate for Previously Treated Patients with Squamous Cell…
Cancer
01 Jan 2013
Eflornithine and Sulindac in Preventing Colorectal Cancer in Patients With Colon Polyps
Rationale: Chemoprevention is the use of certain drugs to keep cancer from forming, growing, or coming back. The use of eflornithine and sulindac may prevent colorectal cancer. It is not yet known whether eflornithine and sulindac are more effective than a placebo in preventing colorectal cancer. Purpose: This randomized…
Cancer
01 Jan 2013
Brain Metastases Study
Purpose- Comparison of radiotherapy fractionation schemes for brain metastasis. Official Title To Determine Which of Two Radiotherapy Brain Fractionation Schemes is Superior in the Treatment of Brain Metastases Conditions Study Type Interventional Study Design Treatment, Randomized, Open Label, Dose Comparison, Parallel Assignment, Efficacy Study Further Details Primary Outcomes: Control of…
Cancer
01 Jan 2013
Immunotherapy Using Cyclosporine, Interferon Gamma, and Interleukin-2 After High-Dose Myeloablative Chemotherapy With Autologous Stem Cell Transplantation in Treating Patients With Refractory or Relapsed Hodgkin’s Lymphoma
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining chemotherapy with autologous stem cell transplantation may allow the doctor to give higher doses of chemotherapy drugs and kill more cancer cells. Giving immunotherapy using cyclosporine, interferon gamma, and…
Bone
01 Jan 2013
A Phase I/II Study of PBPC Mobilisation with VTP195183 Plus G-CSF Compared to Mobilisation with G-CSF Alone
Hematopoietic stem cells (HSC) are used to support the administration of high dose chemotherapy for a range of human cancers. For a safe HSC transplantation, a minimum of 5 million HSC per kilogram are required. HSC are collected from the bone marrow by using drugs such as G-CSF (filgrastim) which…
Cancer
01 Jan 2013
Trial in Locally Advanced and Metastatic Adrenocortical Carcinoma Treatment (FIRM-ACT)
The purpose of this study is to determine whether treatment with etoposide, doxorubicin, cisplatin and mitotane (EDP/M) prolongs survival as compared to streptozotocin and mitotane (Sz/M) in patients with advanced adrenocortical carcinoma (ACC) whose disease is not amenable to complete surgical resection. The Firm-ACT trial is the first ever conducted…
