Cancer
01 Jan 2013
RADAR Trial – Randomised Androgen Deprivation and Radiotherapy
Purpose The principal objectives of the RADAR trial is to address the hypotheses; 1) that 18 months androgen deprivation in conjunction with radiotherapy is superior to 6 months androgen deprivation prior to and during radiotherapy; 2) that 18 months Bisphosphonate therapy will prevent bone loss caused by androgen deprivation…
Cancer
01 Jan 2013
Androgen Deprivation Therapy in Treating Patients With Prostate Cancer
Rationale: Androgens can cause the growth of prostate cancer cells. Androgen deprivation therapy may stop the adrenal glands from making androgens. Purpose: This randomized phase III trial is studying how well androgen deprivation therapy works in treating patients with prostate cancer. Official Title Phase III Randomized Study of Delayed…
Cancer
01 Jan 2013
Chemoradiotherapy in Patients with Localised Lung Cancer
The study compares 2 different methods of combined chemotherapy and radiotherapy for the treatment of localised lung cancer in patients not suitable for surgery. Hypothesis(es) to be tested: 1) Vinorelbine + cisplatin + high-dose palliative radiotherapy is superior to gemcitabine + high dose palliative radiotherapy in terms of efficacy…
Cancer
01 Jan 2013
Tirapazamine, Cisplatin, and Radiation Therapy in Treating Patients With Stage IB, Stage II, Stage III, or Stage IVA Cervical Cancer
RATIONALE: Drugs used in chemotherapy, such as tirapazamine and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Tirapazamine may help cisplatin kill more tumor cells by making tumor cells more sensitive to the drug. Radiation…
Cancer
01 Jan 2013
Combination Chemotherapy After Surgery in Treating Patients With Stage I, Stage II, or Stage III Breast Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. It is not yet known which combination chemotherapy regimen is more effective after surgery in treating breast cancer. PURPOSE: Randomized phase III trial to compare different combination chemotherapy regimens…
Heart
01 Jan 2013
Follow-Up Serial Infusions of Natrecor(R) (Nesiritide) for the Management of Patients with Heart Failure-FUSION II
The purpose of this study is to evaluate the efficacy and safety of Natrecor(R) administered as serial infusions to heart failure (HF) patients in the outpatient setting. Official Title Conditions Heart Failure, Congestive Study Type Interventional Study Design Treatment, Randomized, Double-Blind, Placebo Control, Single Group Assignment, Safety/Efficacy Study Further…
Heart
01 Jan 2013
A Comparison of CS-747 and Clopidogrel in Acute Coronary Syndrome Subjects Who Are to Undergo Percutaneous Coronary Intervention
The sponsors of this investigational drug are developing prasugrel as a possible treatment for patients with acute coronary syndrome (heart attack or chest pain) who need, or are expected to need, a percutaneous coronary intervention (PCI; also called a balloon angioplasty). Prasugrel will be compared with clopidogrel to determine which…
Cancer
01 Jan 2013
Outcomes of Concurrent Chemo-Radiotherapy in Locally Advanced Cervical Cancer.
CCRT is considered the standard of care in LACC since 1999. However there are few reports of results of this treatment in the common practice in developing countries were this disease is most frequent. Official Title Outcomes of Concurrent Chemo-Radiotherapy (CCRT) in Locally Advanced Cervical Cancer (LACC). Results of a…
Chronic Pain
01 Jan 2013
Pain and Stress Management for People with Rheumatoid Arthritis
Self-management of rheumatoid arthritis (RA) symptoms using written emotional disclosure (ED), coping skills training (CST), or a combination of both may benefit people with RA. The purpose of this study is to determine the benefits of ED, CST, or CST and ED together in adults with RA. This study will…
