Cancer
01 Jan 2013
A Study of Xeloda (Capecitabine) Plus Oxaliplatin in Patients With Colon Cancer
This study will compare the efficacy and safety of intermittent oral Xeloda plus Eloxatin with that of fluorouracil/leucovorin in patients who have had surgery for colon cancer and no previous chemotherapy. The anticipated time on study treatment is until disease progression and the target sample size is 500+ individuals. Official…
Cancer
01 Jan 2013
Pilot Efficacy Study of PI-88 With Docetaxel to Treat Prostate Cancer
Docetaxel (Taxotere) is an approved chemotherapeutic drug for the treatment of androgen-independent prostate cancer. The aim of the study is to investigate whether addition of the investigational drug PI-88 will increase the efficacy of docetaxel in this disease. PI-88 inhibits cancer growth by inhibiting the development of new blood vessels…
Cancer
01 Jan 2013
A Multi-Center Study of E7389 Versus Treatment of Physician’s Choice in Patients With Locally Recurrent or Metastatic Breast Cancer
The primary objective of this study is to compare Overall Survival (OS) in patients treated with E7389 versus the Treatment of Physician’s Choice (TPC) in patients with locally recurrent or metastatic breast cancer. Secondary objectives are to assess: Progression Free Survival (PFS) Objective Tumor Response Rate as measured…
Infections
01 Jan 2013
Venticute in Patients With Pneumonia or Aspiration of Gastric Contents and Intubation/Ventilation/Oxygenation Impairment
Study to demonstrate that administration of Venticute increases survival of patients with pneumonia or aspiration of gastric contents leading to intubation, mechanical ventilation, and severe oxygenation impairment. Official Title Venticute in Patients With Pneumonia or Aspiration of Gastric Contents Leading to Intubation, Ventilation, and Severe Oxygenation Impairment: A Randomized, Multinational,…
Research and Trials
01 Jan 2013
Pneumococcal Vaccination of Australian Indigenous Mothers to See If It Protects Their Babies From Ear Disease
PneuMum: A Randomised Controlled Trial of Pneumococcal Polysaccharide Vaccination for Aboriginal and Torres Strait Islander Mothers to Protect Their Babies From Ear Disease clinical trials…
Research and Trials
01 Jan 2013
The Pharmacokinetics of Double Boosted Protease Inhibitors in Antiretroviral-Naive HIV-1 Infected Patients
Treatment with only protease inhibitors might benefit HIV patients. Laboratory data have shown that the combination of saquinavir with lopinavir and ritonavir may a good regimen. This study will explore this idea. Official Title Pharmacokinetics of and Rate of HIV-1 RNA Decline in ARV-Naive HIV-1 Infected Patients Treated With Low-…
Research and Trials
01 Jan 2013
Sensory Cues for Freezing in Parkinson’s Disease
The purpose of this study is (1) to determine if patient triggered sensory (auditory, visual and tactile) cues can help treat freezing of gait in Parkinson’s disease, and (2) to assess if unexpected (randomized) cues are more effective than anticipated ones. Official Title Effect of Randomized Patient-Triggered Sensory Cues for…
Research and Trials
01 Jan 2013
A Study to Evaluate the Efficacy, Safety, and Tolerability of TAK-583 in Subjects With Postherpetic Neuralgia (PHN)
The purpose of the study is to assess the safety and ability of TAK-583 to relieve pain in subjects with PHN, compared with placebo. Official Title A Phase 2, Double Blind, Placebo Controlled, Dose-Ranging Study in Subjects With Postherpetic Neuralgia (PHN) to Evaluate the Efficacy, Safety, Tolerability, and Pharmacokinetics of…
Research and Trials
01 Jan 2013
Sympathetic Activity in Individuals With the Metabolic Syndrome: Benefits of Lifestyle Interventions
An abdominal distribution of fat is associated with the greatest heart disease risk, because commonly, several risk factors of metabolic origin (high blood pressure, unfavourable cholesterol profile, elevated blood sugar, impaired insulin action) cluster in these individuals. When this occurs the condition is called the metabolic syndrome (MetS). The cause…
