Bone
01 Jan 2013
A Study to Assess the Efficacy of Intravenous Bondronat (Ibandronate) in Patients With Malignant and Painful Bone Disease
This study will compare the efficacy of intravenous Bondronat with that of zoledronic acid in patients with malignant bone disease experiencing moderate to severe pain. The anticipated time of study treatment is 6-12 months, and the target sample size is 100-500 individuals Official Title A Randomized, Placebo-Controlled, Double-Blind Study of…
Bone
01 Jan 2013
Trial of Physiotherapy and Corticosteroid Injections in Lateral Epicondylalgia
This randomised controlled trial will evaluate the role of manual therapy and therapeutic exercise and corticosteroid injections in the treatment of lateral epicondylalgia (tennis elbow). Official Title A Pragmatic, Randomised Controlled Trial of Physiotherapy and Corticosteroid Injections in Lateral Epicondylalgia Conditions Tennis Elbow, Musculoskeletal Diseases Study Type Interventional Study Design…
Research and Trials
01 Jan 2013
Effect of Teriparatide Compared to Risedronate on Back Pain in Women With a Spine Fracture Caused by Osteoporosis
The purpose of the study is to determine if daily teriparatide reduces back pain more effectively than weekly risedronate in postmenopausal women with osteoporosis that have back pain due to a spinal bone fracture. Official Title The Effect of Teriparatide Compared With Risedronate on Back Pain in Postmenopausal Women With…
Research and Trials
01 Jan 2013
A Study to Evaluate AMG 162 in the Treatment of Postmenopausal Osteoporosis
This study will evaluate the effectiveness and safety of AMG 162 in treating women with Postmenopausal Osteoporosis. Official Title Conditions Osteoporosis Study Type Interventional Study Design Treatment Further Details Primary Outcome Measures: Reduction in the number of new vertebral fractures in post menopausal osteoporotic women treated with AMG…
Hormones
01 Jan 2013
A Study to Investigate the Effect of Rosuvastatin (CRESTOR) on High Density Lipoprotein Kinetics in Patients With the Metabolic Syndrome
The purpose of this study is to investigate the dose-related effect of treatment with rosuvastatin on production and fractional catabolism of apolipoprotein A-I (apoA-I) and apolipoprotein A-II (apoA-II), and on the plasma apoA-I, apoA-II and high-density lipoprotein cholesterol (HDL-C) concentration. Official Title A Randomised, Double-Blind, Placebo Controlled, Crossover Dose-Ranging Study…
Research and Trials
01 Jan 2013
PROMPT Clinical Trial for Migraine Prevention
Various national and local guidelines demand revision of migraine prevention therapy after 4 to 6 months of treatment. However, there is no evidence from clinical studies to support the validity of such guidance. The PROMPT (PROlonged Migraine Prevention with Topiramate) study was set up to address this issue and evaluate…
Heart
01 Jan 2013
Telmisartan vs. Losartan for Improvement of Renal Function in Hypertensive Diabetic Patients With Overt Nephropathy.
A number of blood pressure lowering drugs in the class known as angiotensin receptor blockers (ARB) have been shown to slow the decline in kidney function of patients with type 2 diabetes, high blood pressure, and kidney disease. Losartan (COZAAR), is one such drug. The purpose of this research study…
Research and Trials
01 Jan 2013
Open Label Tolerability and Safety Study of KRX-101 in Australia, New Zealand, and Hong Kong
The purpose of this study is to assess the tolerability and safety of KRX-101 in treating persistent microalbuminuria in type 2 diabetic patients who are also being treated with stable, maximum tolerated doses of either ACE inhibitors or A2 receptor blockers. Official Title An Open Label Tolerability and Safety Study…
Heart
01 Jan 2013
A Trial of INO-1001 in Patients Undergoing Heart Surgery That Involves Heart-Lung Bypass
The purpose of this study is to assess the safety of INO-1001, an intravenous PARP (poly-polymerase) inhibitor, in patients undergoing heart surgery. The study also measures whether INO-1001 reduces the side effects caused by heart-lung bypass machines. Official Title A Phase II Randomized, Double-Blind, Placebo-Controlled, Multi-Center Study to Evaluate Tolerability,…
