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Heart 01 Jan 2013

CAROLINA: Cardiovascular Outcome Study of Linagliptin versus Glimepiride in Patients with Type 2 Diabetes

The aim of the study is to investigate the long-term impact on cardiovascular morbidity and mortality, relevant efficacy parameters (e.g., glycaemic parameters) and safety (e.g., weight and hypoglycaemia) of treatment with linagliptin in patients with type-2 diabetes at elevated cardiovascular risk receiving usual care, and compare outcome against glimepiride. Official…

Children's health 01 Jan 2013

Metabolic Phenotyping of Individuals Born Following Assisted Reproduction Techniques (IMPART)

This study is to compare the effects of high-fat overfeeding on metabolic risk factors in children born through assisted reproduction technologies (ART) versus children conceived naturally (controls). We will utilise state of the art measures to characterise the physiological, endocrine and molecular responses to high fat overfeeding. The investigators…

Research and Trials 01 Jan 2013

Dose Ranging Efficacy And Safety With Mepolizumab in Severe Asthma (DREAM)

The purpose of this study is to show whether mepolizumab given every 4 weeks intravenously (i.v.) can reduce the frequency of asthma exacerbations in subjects with severe asthma despite receiving high doses of standard asthma medications. The study will look at different doses of mepolizumab in comparison to a placebo.

Research and Trials 01 Jan 2013

CoreValve® System Australia/New Zealand Clinical Study

To evaluate the performance, efficacy and safety of the percutaneous implantation of the CoreValve® prosthetic aortic valve in patients with severe symptomatic native aortic valve stenosis that have an elevated surgical risk Official Title CoreValve® System Australia/New Zealand Clinical Study Conditions Aortic Valve Stenosis…

Research and Trials 01 Jan 2013

To Document the Effectiveness of BoNT-A Injection in Adult Subjects With Upper Limb Spasticity Following Stroke (ULIS2)

The purpose of the study is to assess the responder rate as defined by the achievement of the primary goal from the Goal Attainment Scale following one BoNT-A injection cycle in accordance with routine practices. Official Title An International, Prospective Cohort to Document the Effectiveness of One BoNT-A Injection Cycle…

Children's health 01 Jan 2013

Appropriate Oxygen Levels for Extremely Preterm Infants: a Prospective Meta-analysis (NeOProM)

For over 60 years the most appropriate oxygen level for preterm babies remains unknown. To answer this, we will combine data from over 5300 babies to be sure the expected benefits of lower oxygen for babies’ eyes and lungs does not come at the expense of increasing death or major…

Research and Trials 01 Jan 2013

A Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Prucalopride (Resolor) Tablets in Subjects With Chronic Constipation

The purpose of this study is to compare the efficacy and safety of prucalopride 2 mg given orally once daily for 12 weeks to those of placebo in treatment of chronic constipation. Prucalopride is an investigational drug that is being tested to see if it may be useful in treating…

Research and Trials 01 Jan 2013

A Study in Painful Diabetic Neuropathy (COMBO-DN)

This study will investigate the efficacy of a combination treatment of duloxetine + pregabalin compared with the maximal dose of each drug in monotherapy, in patients with diabetic peripheral neuropathic pain (DPNP) who have not responded to the standard recommended dose of either drug. It will provide an answer to…

Eye Care 01 Jan 2013

Cortical Markers for Glaucoma Research Project

Volunteers are needed for a research study into the effects of glaucoma on the brain. They will require two appointments in total. One of these will be at the Royal Victorian Eye and Ear Hospital, East Melbourne, where they will have a full eye examination and some imaging of…