Hormones
01 Jan 2013
Thyroid and Glucose and Energy Metabolism
This study will examine how two thyroid preparations-levothyroxine (T4) and liothyronine (T3)-affect fat and cholesterol metabolism, blood sugar regulation, and thyrotropin secretion in patients who have had their thyroid gland removed. Results of the study may help in the development of better therapies to optimise blood sugar and cholesterol levels…
Hormones
01 Jan 2013
Consequence of Lifetime Isolated Growth Hormone Deficiency
The primary goal of this proposal is to determine the consequences of life-long lack of GH on body composition, muscle strength, cardiovascular status, cardiovascular risk factors, thyroid status and bone density and metabolism, and to test which of these parameters are reversed by a 6-month course of GH replacement therapy.
Hormones
01 Jan 2013
Growth Hormone as a Determinant of Weight Regulation
With the alarming increase in the prevalence of obesity, identifying factors that predispose individuals to weight-gain is of critical importance. Even when caloric intake and physical activity levels are well controlled, susceptibility for weight-gain is heterogeneous. Basal metabolic rate (BMR) represents the largest portion of daily energy expenditure in normal…
Blood
01 Jan 2013
Ezetimibe/Simvastatin in Patients With Metabolic Syndrome
A 6-week clinical trial in patients with metabolic syndrome and hypercholesterolemia at high risk for coronary heart disease to study the effects of ezetimibe/simvastatin and atorvastatin on lipids. Official Title A Multicenter, Randomized, Double-Blind, Parallel Arm, 6-Week Study to Evaluate the Efficacy and Safety of Ezetimibe/Simvastatin Versus Atorvastatin in Patients…
Heart
01 Jan 2013
SMOOTH – Blood Pressure Control in Diabetic/Obese Patients
The primary objective of the SMOOTH study was to demonstrate that, when combined with hydrochlorothiazide (12.5 mg), telmisartan (80 mg) is at least as effective and possibly superior to valsartan (160 mg) in lowering systolic and diastolic BP during the last 6 hours of the 24-hour dosing interval (i.e., the…
Bone
01 Jan 2013
Study Evaluating the Safety and Efficacy of a Once-Daily Dose of Tigecycline vs Ertapenem in Diabetic Foot Infections with Osteomyelitus
This purpose of this study is to look at the safety and effectiveness of a once-daily dose of tigecycline compared to ertapenem for the treatment of diabetic foot infections with osteomyelitis. Official Title A Multicenter, Randomized, Double-Blind, Comparison Study of the Safety and Efficacy of a Once-Daily Dose of Tigecycline…
Children's health
01 Jan 2013
Rosiglitazone and Insulin in T1DM Adolescents
Type 1 Diabetes is the most common life-long disorder with onset in childhood. Patients need insulin injections, blood sugar monitoring several times each day, and adhere to a strict diet. Adequate control of blood glucose is essential to prevent long term kidney and eye complications that result in kidney failure…
Hormones
01 Jan 2013
A 1-Year Study On The Effects Of CP-945,598 For The Treatment Of Obesity In Overweight Type 2 Diabetic Patients
The purpose of this study is to determine if CP-945,598 is effective in the treatment of obesity in type 2 diabetic patients. Official Title A 1-Year, Randomized, Double-Blind, Placebo-Controlled Phase 3 Study To Evaluate The Efficacy And Safety Of CP-945,598 In The Treatment Of Overweight, Oral Agent-Treated Subjects With Type…
Hormones
01 Jan 2013
Comparison of Two Approaches to Insulin Therapy in Patients With Type 2 Diabetes
A study of patients with type 2 diabetes who are not controlled on two or more oral antihyperglycemic agents comparing adding insulin lispro mid mixture to the oral antihyperglycemic agents to adding insulin glargine to the oral antihyperglycemic agents. Official Title Comparison of Two Approaches to Basal-Bolus Insulin Therapy in…
