Ototoxicity refers to drug or chemical-related damage to the inner ear resulting in impairment the organs responsible for hearing and balance. Such damage can result in temporary or permanent hearing loss and/or disequilibrium. Ototoxic substances include several therapeutic medicines such as aminoglycoside antibiotics, some platinum based anti-cancer agents, loop diuretics, anti-malarial drugs and aspirin as well as other environmental substances such as mercury, lead and arsenic.
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