IgE is the largest immunoglobulin, but is present at extremely low levels in a healthy individual. An immunoglobulin (or antibody) is a protein produced by B cells, which is involved in immune responses. IgE has a high affinity for mast cells, causing them to release substances that stimulate an allergic reaction. Allergic conditions such as hayfever and allergic rhinitis are caused by an abnormal immune system response, which stimulates the production of too much IgE.
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