P450 enzyme inhibitors or inducers can alter the level of antibiotics present in the blood stream, increasing the risk of potential drug interaction. Common enzyme inhibitors include: erythromycin, ketoconazole, metronidazole, cotrimoxazole, statins (ie Simvastatin, Pravastatin), omeprazole, amiodarone and allopurinol. If an antibiotic is administered in the presence of an enzyme inhibitor, depending on it’s method of elimination, it’s level will most likely increase.
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