Cancer
01 Jan 2013
Combination Chemotherapy Plus Radiation Therapy in Treating Children With Newly Diagnosed Brain Stem Glioma
Phase I trial to study the effectiveness of vincristine plus etoposide and radiation therapy in treating children who have newly diagnosed brain stem glioma.Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor…
Children's health
01 Jan 2013
Hib-MenCY-TT Vaccine Study Compared to Licensed Hib and Meningococcal Serogroup C Conjugate Vaccines
This study is evaluating the safety and immunogenicity of Hib-MenCY-TT vaccine compared to control groups receiving licensed Hib or MenC conjugate vaccines, each administered at 2, 4, 6, and 12 to 15 months of age. Co-administration with live, attenuated measles, mumps, and rubella combination vaccine; and with live, attenuated varicella…
Children's health
01 Jan 2013
Study Evaluating Safety & Immunogenicity of rLP2086 Meningitis Vaccine in Adolescents
Study to evaluate the safety of an investigational meningitis vaccine and the immune response to it in adolescents Official Title A Randomized, Observer-Blinded, Parallel-Group, Active-Control, Phase 1/2 Trial of the Safety, Immunogenicity, and Tolerability of 20 micrograms, 60 micrograms, and 200 micrograms of Meningococcal Group B rLP2086 Vaccine in Healthy…
Children's health
01 Jan 2013
Prevention of Asthma With Levocetirizine (36 Month Treatment) in Young Children Suffering From Eczema (Atopic Dermatitis) and Sensitized to Grass Pollen and House Dust Mite and Having Completed the Previous EPAAC Trial
36 months study to evaluate the efficacy and safety of levocetirizine (LCTZ) in preventing the onset of asthma in young atopic children. Official Title The Prolongation of the EPAAC Trial (The Early Prevention of Asthma in Atopic Children). A Multi-Country, Double Blind, Placebo (PLC) Controlled, Follow-up Trial With 3 Parallel…
Cancer
01 Jan 2013
The IVADo regimen for children with metastatic soft tissue sarcoma
Objectives: To evaluate the feasibility of an intensified induction regimen (IVADo), which combines doxorubicin, with the well established ifosfamide, vincristine and actinomycin D (IVA) regimen. Conclusions from the authors: The intensive IVADo regimen was effective against pediatric STS with acceptable toxicity. This combination will be investigated in high-risk…
Blood
01 Jan 2013
Transfusion Medicine/Hemostasis Clinical Research Network
To establish a clinical network which will promote the efficient comparison of new management strategies of potential benefit for children and adults with hemostatic disorders such as idiopathic thrombocytopenia (ITP) and thrombotic thrombocytopenic purpura (TTP). The network also will evaluate new as well as existing blood products and cytokines for…
Children's health
01 Jan 2013
An Outpatient Study of the Effectiveness and Safety of Depakote ER in the Treatment of Mania/Bipolar Disorder in Children and Adolescents
The purpose of this study is to determine the safety and effectiveness of Depakote ER (Divalproex Sodium Extended-Release Tablets) compared to placebo in the treatment of bipolar disorder, manic or mixed type in children and adolescents ages 10-17 years. Official Title Conditions Bipolar Disorder Study Type Interventional Study Design Treatment…
Bone
01 Jan 2013
A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study of the Safety, Efficacy, and Pharmacokinetics of the Human Anti-TNF Monoclonal Antibody Adalimumab in Children With Polyarticular Juvenile Rheumatoid Arthritis
This is a multicenter, Phase III randomized, placebo-controlled study in which polyarticular JRA subjects who are either MTX treated or non-MTX treated will initially receive Adalimumab by subcutaneous injection every other week for a four-month open-label lead-in period. Subjects who respond to the open-label therapy will then be rolled over…
Children's health
01 Jan 2013
Early Antipseudomonal Therapy in Cystic Fibrosis
To determine a safe, effective, and systematic approach to antibiotic treatment of Pseudomonas infection in young children with cystic fibrosis. Official Title Conditions – Cystic Fibrosis- Infection- Lung Diseases Study Type Interventional Study Design Prevention, Randomized Further Details BACKGROUND: Cystic fibrosis (CF), an autosomal recessive disorder without a cure,…
