Linkage analysis (also known as indirect gene tracking) is a technique used in the identification of inherited disease genes.
The technique is based on the fact that special DNA sequences that flank particular genes will travel with the gene when passed from parent to child. These DNA sequences are called ‘polymorphic markers’ or ‘polymorphic repeat sequences’. If a particular polymorphic marker is found only in members of a family with a particular disease then it is likely that a gene located near the marker is associated with the disease.
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