Dependence is the physical need for a certain substance. Dependence describes the state where taking a pharmacological agent becomes compulsive and takes precedence over other needs. This is the newer term for drug addiction.

When a person is dependant on a substance, they will experience withdrawal symptoms if they do not receive it. Dependence can be both physical and emotional. A sign of physical dependence is when an individual becomes tolerant to a substance. This means that the effect of the substance decreases over time and a larger dose is required to exert the same effect as the original dose had.

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