Critical limb ischaemia is a condition in which the blood flow to a limb is obstructed. The obstruction in some cases can be so severe that wounds form which do not heal and gangrene can occur in the affected limb. Patients that have been treated with SCS for critical limb ischaemia have reported an increased health-related quality of life; experiencing improved pain relief, limb survival and an initial reduction in the need for the use of analgesics.

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