Anti-vascular endothelial growth factor (anti-VEGF) is a drug that impairs the activity of VEGF, a chemical produced by the body that stimulates the growth of blood vessels. Anti-VEGF binds to VEGF and interrupts the signals VEGF normally sends to stimulate blood vessel growth. It is used to treat conditions of abnormal and excessive blood vessel growth such as wet macular degeneration, in which blood vessels grow excessively in the eye‘s retina and macula.