Lungs
01 Jan 2013
Study Evaluating the Safety and Efficacy of Infliximab in Subjects with Moderate to Severe Chronic Obstructive Pulmonary Disease
The purpose of this study is to determine the safety and efficacy of infliximab in patients with moderate to severe Chronic Obstructive Pulmonary Disease. Official Title A Phase II, Multicenter, Randomized, Double-blind, Placebo-controlled Parallel Group, Dose Finding Study Evaluating the Safety and Efficacy of Infliximab Administration in Symptomatic Subjects with…
Lungs
01 Jan 2013
Study of the Disease Process of Lymphangioleiomyomatosis
Pulmonary lymphoangioleiomyomatosis (LAM) is a destructive lung disease typically affecting women of childbearing age. Currently, there is no effective therapy for the disease and the prognosis is poor. Official Title Characterization of the Pathogenesis of Lymphangioleiomyomatosis (LAM) Conditions – Leiomyomatosis- Lung Disease- Pneumothorax- Tuberous Sclerosis Study Type Observational Study…
Infections
01 Jan 2013
Intrathecal Gemcitibine to Treat Neoplastic Meningitis
Gemcitabine is an investigational drug for treatment of neoplastic meningitis (cancer that has spread to the lining of the brain and spinal cord). The purposes of this study are: to determine the highest dose of gemcitabine, an anti-cancer drug, that can safely be given directly into the spinal fluid…
Infections
01 Jan 2013
Experimental Ebola Vaccine Trial
This study will test the safety of an experimental vaccine developed to protect against Ebola virus infection and to determine if the vaccine induces an immune response to the virus. The Ebola virus causes a disease called Ebola hemorrhagic fever. Symptoms begin with fever and muscle aches and progress to…
Infections
01 Jan 2013
Assessment of valganciclovir in neonates with CMV
Primary: -To determine the pharmacokinetics of ganciclovir following administration of oral valganciclovir syrup in neonates and young infants with symptomatic congenital CMV disease -To identify a dose of valganciclovir to provide comparable ganciclovir plasma concentrations in neonates and young infants with symptomatic congenital CMV disease. Secondary: -To evaluate…
Gastro
01 Jan 2013
Barrett’s Esophagus Early Detection Study
The incidence rate for esophageal adenocarcinoma (EAC) has risen 10% per year over the past two decades and is the most rapidly increasing cancer in the U.S. Potential reasons for this increase include obesity and gastroesophageal reflux disease (GERD). Prevention strategies to date have focused on early detection. Barrett’s esophagus…
Mental Health
01 Jan 2013
MRI Study of Brain Activity and Risk for Depression in Adolescents
This study will use magnetic resonance imaging (MRI) to investigate brain changes in adolescents at risk for Major Depressive Disorder. It also calls for healthy volunteers to compare to children at risk for major depression. Official Title Neural Circuitry and Risk for Depression in Adolescents: A Study Using Functional Magnetic…
Mental Health
01 Jan 2013
Preventing the Recurrence of Depression with Drugs and Psychotherapy
The purpose of this study is to determine whether the addition of Cognitive Therapy (CT) to antidepressant medication (ADM) enhances treatment for depression. This study will also test whether the addition of CT to ADM will prevent recurrences of depression after therapy is over. Official Title Prevention of Recurrence in…
Gastro
01 Jan 2013
Peg-Intron for Prevention of Disease Progression in Chronic Hepatitis C Patients with Cirrhosis (failing with Interferon plus Ribavirin treatment)
The objective of the study is to evaluate the safety and efficacy of PEG-Intron vs. no treatment for the prevention of disease progression in adult subjects with compensated cirrhosis secondary to chronic hepatitis C, who failed to respond to therapy with an a interferon plus ribavirin. Official Title Peg-Intron for…
